Abstract: Objective To evaluate the effect of tuberculosis control program carried out in Dongguan city and to determine the initial drug resistance level.Method Drug resistance surveillance(DRS) was implemented in Dongguan according to WHO/IUATLD Guidelines for Surveillance of Drug Resistance in Tuberculosis(1994).The proportional method was used for new smear-positive pulmonary tuberculosis without history of anti-tuberculosis drug use.Results Among 558 cases,the rate of initial resistance was 18.1%.The resistant rate to isoniazid was 9.9% and streptomycin was 11.6%.Those two drugs were the major resistance drugs.The resistant rate to one drug was 50.5% among the patients with resistance results.The treatment outcomes were good not only in new susceptibility cases but also in initial drug resistant cases.Conclusion The result revealed that the drug resistance level in Dongguan was high.Therefore,TB control program should be further strengthened.

Key words: Tuberculosis/prevention and control, Drug resistance,bacterial, Dongguan