Abstract: Objective To observe the change of CD4 and CD8 lymphocytes in pulmonary tuberculosis patients and to explore the trend and significance of their immune function Methods Determine the CD4 and CD8 values in 31 adult pulmonary tuberculosis patients and 12 control cases with flow cytometry. And then make a statistical analysis based on the determining Results .Results The CD4 values of the patients declined obviously, the CD8 values had no obvious difference . There was no obvious relationship between the decline extent of CD4 values and the patients’ illness condition, the condition of the discharge of bacteria. Conclusion Damage of cellular immune function existed in the adult pulmonary tuberculosis patients, which prominently manifested in the form of the decline of the CD4T lymphocytes , but it had no absolute effective impact on the occurrence and development of illness.

Key words: Tuberculosis, pulmonary, CD4 cell, CD8 cell