Abstract: Objective To study the preventive efficacy of Silybin meglumine tablets on medicamentous liver lesion by antituberculosis drugs. Methods 242 sputum positive initial treated pulmonary tuberculosis were divided into two groups, study group and control group randomly,which were both treated by chemotherapy regimen of 2HRZS(E)/4HR.The study group also took TSM. Results In the study group the morbidity of medicamentous liver lesion was 6.6%,the incidence rate of interrupting treatment was 4.1%,1.6%of cases adjusted the antituberculosis regemen. And the control group was 19.2%,14.2% and 19.2% respectively.There were very significant difference between the two groups(P<0.01).Conclusion Silybin Meglumine tablets can obviously decrease the incidence rate of liver damage of sputum positive initial treated patients induced by antituberculosis drugs and decrease or prevent the irregular chemotherapy that Results from the liver damage caused by antituberculosis drugs.

Key words: pulmonary tuberculosis/drug therapy, liver lesion, Silybili Meglumine tablets