Abstract: Objective To evaluate the clinical treatment outcome and safety of the treatment approaches for multi-drug resistance pulmonary tuberculosis with containing drug gelatin by fiberbronchoscope.Methods The matients were treated with containing drug gelatin by bronchofiberscope and antituberculosis treatment in experiment group;the patients were treated only by antituberculosis treatment in control group.The clinical treatment outcome were observed.Results At the end of six months therapy,the sputum conversion rate was 73.1%,foci marked absorption rate was 85.4%,and cavity curative effect rate was 81% in experiment group,all of which were higher than that of the controls (51.3%, 56.7% and 51.4%)(P＜0.05).The duration of sputum conversion time was 36.3d in experiment group,it was shorter than that of the controls (61.8 d),(P＜0.01).There were not severe adverse reaction observed in experiment group.Conclusion The efficiency of the containing drug gelatin by fiberbronchoscoope combined with routine antituberculosis treatment is better than the routine antituberculosis treatment only.The treatment approaches were effective and safe in treatment of multi-drug resistance pulmonary tuberculosis.

Key words: Pulmonary tuberculosis/drug therapy, Multidrug-resistant