Abstract: Objective To observe and analyse the therapeutic effects of individualized regimens for 69 patients with multi drug resistant pulmonary tuberculosis (MDR TB).Methods The patients were divided into 3 groups according to the result of susceptibility test.Three groups were HR resistant group (Group Ⅰ),resistant to 3 drugs including HR (Group Ⅱ) and resistant to 4 or more drugs including HR group (Group Ⅲ).And the patients received individualized regimens for treatment.Sputum negative conversion rates and chest X ray improvement rates were observed.Results The sputum conversion rates and chest X ray improvement rates of 3 groups in the treatment of 6,12 and 24 months:the sputum conversion rates and chest X ray improvement rates in Group Ⅰ were 76.5%,94.1%,94.1,94.1,Group Ⅱ were 60.0%,65.0%,70.0%,80.0% and Group Ⅲ were 46.9%,50.0%,46.9%,56.3% respectively.The rates of Group Ⅰ were higher significantly than that of Group Ⅲ ( P<0.05,P<0.01,P<0.01). There was no difference between Group Ⅰ and Ⅱ/Conclusion Individualized regimens therapeutic effects were associated with the number of resistant drugs and irreversible lesions.Our Results obtained in this study suggested that timely individualized regimens were provided to MDR TB patients based on the susceptibility test is improtant for the treatment.

Key words: Tuberculosis pulmonary/drug therapy, Tuberculosis,multidrug resistant, Individuation