Abstract: Objective To analyze the characteristics of IS6110 restriction fragment length polymorphism ( RFLP ) patterns of mycobacterium tuberculosis strains isolated from Jilin City.Methods 53 of Mycobacterium tuberculosis strains were isolated from the 53 cases with pulmonary tuberculosis,IS6110 RFLP patterns were produced by DNA fingerprinting. Mycobacterium tuberculosis strains were divided into groups according to their homology of IS6110 fingerprinting,and were analyzed.Results The characteristics of IS6110 RFLP patterns of Mycobacterium tuberculosis strains isolated from Jilin City showed:(1)The average of the copies of IS6110 was 13.(2)The homology of the strains between group A and group B existed to a great extent.They had the characteristic of "Beijing genotype strains".Strains in group C had high polymorphism.(3)The characteristics of IS6110 patterns were not related to the geographic distribution of the patients.(4)The clustering rate of strains in initial cases of drug resistance was high;as for the characteristic of the patterns,there were no differences between the strains of drug resistance and those of non drug resistance.Conclusion The main type of the IS6110 RFLP patterns of Mycobacterium tuberculosis strains in Jilin City was "Binjing genotype strains",but there was a feature specially,that was the high polymorphism.

Key words: Mycobacterium,tuberculosis, DNA fingerprint, Jilin city