Abstract:

Based on the “State-Target” theory proposed by Academician Tong Xiaolin, this study systematically elucidates the dynamic evolution of lymph node tuberculosis, establishes a “three-stage and four-state” syndrome differentiation framework. Within this framework, deeply analyzes the “state-regulating” and “target-hitting” mechanisms of the clinical empirical formula Sanjie Tie (Dispersion Plaster) in the external treatment of lymph node tuberculosis during the ulcerative stage. The disease course of lymph node tuberculosis follows a dynamic pathological evolution pathway of “stagnation (qi stagnation and phlegm coagulation, early stage)→stasis (phlegm and blood stasis, early stage)→fire (yin deficiency and fire effulgence, middle stage)→deficiency (qi and blood deficiency, late stage)”. For the core pathogenesis of “lingering heat stasis with qi-blood deficiency” in the ulcerative stage, Sanjie Plaster uses Huangqi (Astragali Radix) to tonify qi and nourish blood, eliminate toxins and promote tissue regeneration; and employs Danshen (Salviae Miltiorrhizae Radix), Tianhuafen (Trichosanthis Radix), Ruxiang (Olibanum) and Moyao (Myrrha) to clear heat and resolve stasis for state regulation. Meanwhile, it achieves target-striking effects through multi-components and multi-pathways, including promoting wound healing, alleviating pain, regulating abnormal cytokine levels and enhancing immune function, thus realizing the synergy of state and target as well as the combination of internal and external treatment. The “State-Target” theory provides an innovative theoretical framework for the precise differentiation and treatment of lymph node tuberculosis in traditional Chinese medicine, and the external treatment with Sanjie Tie demonstrates clear clinical efficacy and promotional value under the guidance of the theory.

Key words: Tuberculosis, lymph node, Medicine, Chinese traditional, Sanjie plaster