Table of Content

20 April 2011, Volume 33 Issue 4

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A study on the correlation between the polymorphism of HLA-DR、DQ genes and the susceptibility to pulmonary tuberculosis in a Uyghur population from Xinjiang

Wang Xi,Ren Lingjun,Li Xiuling,Wu Fang,Zhang Le,Zhang Wanjiang

Chinese Journal of Antituberculosis. 2011, 33(4):  197-203. 

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Objective To explore the correlation between the polymorphism of HLA-DRB1、DQB1 genes and the susceptibility to pulmonary tuberculosis (PTB) in a Uyghur population from Xinjiang.  Methods Using case-control study, HLA-DRB1、DQB1 genotypes in 226 PTB cases and 231 healthy controls from Uyghur population in Xinjiang were analyzed with polymerase chain reaction-sequence specific primers (PCR-SSP), in which gene frequency (GF) and odds ratio (OR) were calculated and compared.  Results 1.The frequency of HLA-DRB1*11 gene in PTB cases was significantly higher than that in the healthy controls (OR=4.388, 95%CI=1.618—11.905, P_c＜0.05), their GFs were 4.5% and 1.1% respectively. The frequency of HLA-DRB1*04 gene in PTB cases was higher than that in the healthy controls, but there was the statistical difference (OR=1.686, 95%CI=1.060—2.684, P_c>0.05), their GFs were 12.8% and 8.4% respectively.   2. The frequency of HLA-DQB1*0201 gene in PTB cases was significantly higher than that in the healthy controls (OR=3.379, 95%CI=2.302—4.960, P_c＜0.05), their GFs were 40.1% and 19.2% respectively. The HLA-DQB1*0301/4 gene occurred less frequently in TB patients than in controls, but there was the statistical difference (OR=0.561, 95%CI=0.334—0.941, P_c＞0.05), their GFs were 6.2% and 10.3% respectively.  Conclusion HLA-DRB1*11 and DQB1*0201 alleles were evidently correlated to the incidence of tuberculosis, maybe susceptible genes of tuberculosis in Xinjiang Uyghur population.

Relationship between toll-like receptor 2 gene polymorphism and pulmonary tuberculosis in Chinese Han population

Che Nanying,Jiang Shiwen,Gao Tiejie,Li Song,Zhang Xuxia,Zhang Hui,Zhang Zhiguo,Wang Lixia,Li Chuanyou

Chinese Journal of Antituberculosis. 2011, 33(4):  204-208. 

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Objective To study the relationship between toll-like receptor 2 (TLR2) gene polymorphisms and susceptibility to pulmonary tuberculosis in Chinese Han population.  Methods TLR2 gene polymorphisms were analyzed by DNA sequencing in a small amount of samples. SNPs in TLR2 gene were detected by ligase detection technique in a large amount of samples. The relationship between TLR2 gene polymorphisms and susceptibility to pulmonary tuberculosis were analyzed by statistic Methods .  Results Six gene polymorphisms were found, but there were no significant differences between pulmonary tuberculosis patients and healthy controls by allelic and genotypic analysis (P>0.05).  Conclusion TLR2 gene polymorphisms are not risk factors for susceptibility to pulmonary TB in Chinese Han population.

 Study on the application of proteomic fingerprinting in the differential diagnosis of tuberculosis and lung cancer

Wang Lin,Weng Lizhen,Li Xueling,Huang Mingxiang,Guo Qiaoling,Fang Sufang,Zhang Lishui,Chen Xiaohong,Zheng Xiaohu,Liu Tanye

Chinese Journal of Antituberculosis. 2011, 33(4):  209-213. 

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Objective To explore the use of surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) technology in the differential diagnosis of pulmonary tuberculosis and lung cancer.  Method The serum samples were collected from 65 tuberculosis patients and 65 lung cancer patients. Serum proteins were captured using WCX2 chips, then scanned and analyzed using chip reader PBSⅡ.  Results Comparing the serum protein data from 65 pulmonary tuberculosis cases and 65 lung cancer cases, four protein peaks (5 335 m/z, 8 048 m/z, 11 700 m/z, and 11 683 m/z) were significantly different between tuberculosis and lung cancer (P<0.01). This diagnostic model had an accuracy of 74.6% (97/130), sensitivity of 80% (52/65)，and specificity of 69.2% (45/65).  Conclusions SELDI-TOF-MS technique can potentially provide a new simple, rapid, and non-invasive method for the differential diagnosis of tuberculosis and lung cancer patients.

Quantitative study of indicators in monitoring and evaluation system of national tuberculosis program

Jiang Shiwen,Zhang Hui,Li Xinxu,Li Weibin,Liu Xiaoqiu,Xie Haibo,Li You,Wang Lixia

Chinese Journal of Antituberculosis. 2011, 33(4):  214-218. 

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Objective To determine the quantitative standard of monitoring and evaluation indicators, and provide the reference frame for the establishment of ME indicator system. Method From July 2007 to June 2008, Synthetically scored method was used to evaluate the quantification and their standards of ME indicators. Result Thirty experts were invited, and the callback rate of questionnaires was 100.0%. In the ME indicator system, there are 10 classes of 69 indicators. Of those, 10 among 11 indicators related to government commitment, 14 among 18 indicators related to case detection, 10 among 14 indicators related to treatment and management, and 19 among 26 indicators related to laboratory, registration and reporting, drug supply and management can be quantified. Conclusion The proportion of monitoring and evaluation indicators which could be quantified is high. The quantificational standards of indicators could better direct the actual work of NTP.

Factors affecting treatment failure of new smear positive pulmonary tuberculosis patients

Chen Qichen,Tan Shouyong,Guo Wanru,Liu Jianxiong,Xue Zhiqiang

Chinese Journal of Antituberculosis. 2011, 33(4):  219-226. 

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Objective To explore the risk factors affecting treatment failure of new smear positive pulmonary tuberculosis in order to provide recommendations for reducing treatment failure. Methods This is a 1∶1 case-control study. 367 treatment failure cases of new smear positive pulmonary tuberculosis registered from 2003 to 2009 in Guangzhou City were selected in the case group; control cases are matched on living district, gender, and age and treatment completion date. Univariate and multiple conditional Logistic regressions were made for analysis. Results 22 significantly different factors are identified through univariate analysis, among which, the top ten factors with higher OR value are irregular medication (19.54), doseager eduction (7.92), smear-positive at the end of 3 months (7.88), liver function damage (7.79), endobronchial tuberculosis (6.05), smear-positive at the end of 2 months (5.17), primary drug-resistant (4.26), hypoalbuminemia (3.01), self management (2.91), diabetes (1.84); Thirteen factors are selected into the regression equation. Among them, factors with higher OR value are irregular medication (15.93), dosage reduction (8.91), primary drug-resistant (5.02), smear-positive at the end of 3 months (3.21), adverse drug response (2.30), smear-positive at the end of 2 months (2.70), Among them, economic status (1.51) is a protective factor. Conclusion irregular medication, dosage reduction, primary drug resistance, smear positive at the end of 2,3 month, adverse drug response are the main factors of treatment failure, the economic situation is protective factor. It is important to adopt corresponding intervention measures against the risk factors in order to reduce treatment failure.

Analysis of the factors affecting the economic burden of floating population living with pulmonary tuberculosis

Wang Xu,Qi Wei,Zhang Dan,Chen Shiqiang,Pang Xuewen,Li Jingxin,Li Shanglun

Chinese Journal of Antituberculosis. 2011, 33(4):  227-231. 

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Objective To study the current economic burden of the population of patients with pulmonary tuberculosis to investigate the influencing factors for tuberculosis prevention and control of the floating population to provide evidence.  Methods Human Capital Method was used in the calculation of economic burden of patients and Single Regression Analysis was used to analyze the risk factors of economic burden. Results The per-capita direct economic burden of inpatient was 6 280 RMB, and the indirect economic burden was 3 180.13 RMB; the per-capita direct economic burden of outpatient was 1 325 RMB, and the indirect economic burden was 718.25 RMB. The main risk factors include age, gender, smear result and hospitalization.  Conclusion For floating pulmonary tuberculosis, the economic burden of inpatients is heavier than outpatients. The incentives provided by the project significantly reduced the direct economic burden of patients.

 Analysis on status and trend of tuberculosis mortality from 2004 to 2008 in China

Hu JiaWang Lixia,Chen Wei,Huang Fei,Zhang Hui,Cheng Shiming,Zhou Maigeng,Wang Lijun

Chinese Journal of Antituberculosis. 2011, 33(4):  232-237. 

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Objective To understand the status and trend of tuberculosis mortality from 2004 to 2008 in China.  Method Tuberculosis mortality was obtained by national disease surveillance points, gender, age and geographical distribution of TB death were analyzed. Results From 2004 to 2008, the tuberculosis mortality decreased from 6.57/100 000 to 3.90/100 000, the average annual mortality rate was 5.78/100 000, 7.81/100 000 for male and 3.66/100 000 for female, 3.57/100 000 for urban and 6.98/100 000 for rural people, 3.66/100 000,4.97/100 000 and 9.61/100 000 for eastern, middle and western region of China respectively. For pulmonary tuberculosis the average annual mortality rate was 5.48/100 000, 7.45/100 000 for male and 3.40/100 000 for female, 3.34/100000 for urban and 6.63/100 000 for rural people, 3.44/100 000,4.72/100 000 and 8.98/100 000 for eastern, middle and western region of China respectively. Conclusion There is a declining trend for tuberculosis mortality in China. However, it is still high in the western, rural and elderly population. Therefore, we should develop effective intervention measures for different types of tuberculosis, regions and target population.

Comparison of lipiodol bronchography and HRCT for diagnosing bronchiectasis(study of 26 cases)

Zhao Zegang,Xie Ruming,Lv Yan,Zhou Xinhua

Chinese Journal of Antituberculosis. 2011, 33(4):  238-242. 

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Objective To evaluate the value of the lipiodol bronchography and high resolution computerized tomography(HRCT) in the diagnosis of bronchiectasis. Methods Both lipiodol bronchography and HRCT were performed in 26 cases with bronchiectasis, the similarities and differences of characteristics were analyzed. Results The diagnostic rate was 76.9% in lipiodol bronchography and 100% in HRCT among 26 cases. Lipiodol bronchography was better in the performance of bronchial wall irregularly and stiffly than that of HRCT (P<0.01). However, HRCT was better in the performance ofbronchial wall thickening and bronchodilation of pulmonary segment and subsegment than that of lipiodol bronchography. For mild bronchiectasis, lipiodol bronchography was more visual with contrast of the display in other parts of the same level bronchus than that of HRCT. But multiplanar reformations(MPR) in HRCT can make up for these deficiencies. Conclusion HRCT should be considered as the first choice for diagnosing bronchiectasis，the lipiodol bronchographyis often used as the secondary choice for examination.