Relationship between toll-like receptor 2 gene polymorphism and pulmonary tuberculosis in Chinese Han population

Abstract

Abstract: Objective To study the relationship between toll-like receptor 2 (TLR2) gene polymorphisms and susceptibility to pulmonary tuberculosis in Chinese Han population.  Methods TLR2 gene polymorphisms were analyzed by DNA sequencing in a small amount of samples. SNPs in TLR2 gene were detected by ligase detection technique in a large amount of samples. The relationship between TLR2 gene polymorphisms and susceptibility to pulmonary tuberculosis were analyzed by statistic Methods .  Results Six gene polymorphisms were found, but there were no significant differences between pulmonary tuberculosis patients and healthy controls by allelic and genotypic analysis (P>0.05).  Conclusion TLR2 gene polymorphisms are not risk factors for susceptibility to pulmonary TB in Chinese Han population.

Key words: tuberculosis,pulmonary, Toll-like receptor 2, polymorphism genetic, genetic predisposition to disease, Han notionality

CLC Number:

R521

Che Nanying,Jiang Shiwen,Gao Tiejie,Li Song,Zhang Xuxia,Zhang Hui,Zhang Zhiguo,Wang Lixia,Li Chuanyou. Relationship between toll-like receptor 2 gene polymorphism and pulmonary tuberculosis in Chinese Han population[J]. Chinese Journal of Antituberculosis, 2011, 33(4): 204-208.

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