Chinese Journal of Antituberculosis ›› 2020, Vol. 42 ›› Issue (6): 583-589.doi: 10.3969/j.issn.1000-6621.2020.06.009
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HONG Chuang-yue, YANG Ting-ting, LI Jin-li, LI Shuang-jun, WU Li-kai, YANG Zheng, TAN Wei-guo()
Received:
2020-03-16
Online:
2020-06-10
Published:
2020-06-11
Contact:
TAN Wei-guo
E-mail:twg202@163.com
HONG Chuang-yue, YANG Ting-ting, LI Jin-li, LI Shuang-jun, WU Li-kai, YANG Zheng, TAN Wei-guo. Analysis of characteristic of resistant gene mutations among multidrug-resistant Mycobacterium tuberculosis in Shenzhen[J]. Chinese Journal of Antituberculosis, 2020, 42(6): 583-589. doi: 10.3969/j.issn.1000-6621.2020.06.009
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药品 | 基因突变株数 | 突变率(%) | 突变基因类型 | 株数 | 构成比(%) | |||||
---|---|---|---|---|---|---|---|---|---|---|
INH | 432 | 96.6 | katG-315-S/T | 353 | 81.7 | |||||
inhA-15-C/T | 27 | 6.3 | ||||||||
katG-315-S/N | 10 | 2.3 | ||||||||
katG-315-S/T+inhA-15-C/T | 9 | 2.1 | ||||||||
其他 | 33 | 7.6 | ||||||||
RFP | 432 | 96.6 | rpoB-450-S/L | 258 | 59.7 | |||||
rpoB-445-H/Y | 15 | 3.5 | ||||||||
rpoB-445-H/N | 15 | 3.5 | ||||||||
rpoB-445-H/D | 14 | 3.2 | ||||||||
rpoB-430-L/P | 12 | 2.8 | ||||||||
rpoB-445-H/L | 11 | 2.5 | ||||||||
rpoB-435-D/V | 9 | 2.1 | ||||||||
rpoB-452-L/P | 8 | 1.8 | ||||||||
rpoB-441-S/Q | 7 | 1.6 | ||||||||
rpoB-430-L/P+rpoB-445-H/N | 7 | 1.6 | ||||||||
rpoB-445-H/R | 6 | 1.4 | ||||||||
rpoB-430-L/P+rpoB-435-D/G | 6 | 1.4 | ||||||||
rpoB-445-H/R+rpoB-445-H/N | 5 | 1.2 | ||||||||
其他 | 59 | 13.7 | ||||||||
EMB | 265 | 59.3 | embB-306-M/V | 94 | 35.5 | |||||
embB-306-M/I | 53 | 20.0 | ||||||||
embB-497-Q/R | 20 | 7.5 | ||||||||
embB-406-G/D | 13 | 4.9 | ||||||||
embB-406-G/A | 12 | 4.5 | ||||||||
embB-306-M/L | 10 | 3.8 | ||||||||
embB-354-D/A | 10 | 3.8 | ||||||||
embB-406-G/S | 9 | 3.4 | ||||||||
embB-1024-D/N | 5 | 1.9 | ||||||||
其他 | 39 | 14.7 | ||||||||
PZA | 123 | 27.5 | pncA启动子-11-T/C | 11 | 8.9 | |||||
pncA-141-Q/* | 9 | 7.3 | ||||||||
pncA-159-L/R | 6 | 4.9 | ||||||||
pncA-175-M/V | 6 | 4.9 | ||||||||
pncA-76-T/P | 6 | 4.9 | ||||||||
pncA-142-T/A | 5 | 4.1 | ||||||||
其他 | 80 | 65.0 | ||||||||
药品 | 基因突变株数 | 突变率(%) | 突变基因类型 | 株数 | 构成比(%) | |||||
Sm | 300 | 67.1 | rpsL-43-K/R | 198 | 66.0 | |||||
rpsL-88-K/R | 47 | 15.7 | ||||||||
rrs-1401-A/G | 8 | 2.7 | ||||||||
rrs-514-A/C | 21 | 7.0 | ||||||||
rpsL-43-K/R+rrs-1401-A/G | 13 | 4.3 | ||||||||
其他 | 13 | 4.3 | ||||||||
Ofx | 124 | 27.7 | gyrA-90-A/V | 39 | 31.5 | |||||
gyrA-94-D/G | 37 | 29.8 | ||||||||
gyrA-94-D/A | 16 | 12.9 | ||||||||
gyrA-94-D/N | 8 | 6.5 | ||||||||
gyrA-94-D/Y | 7 | 5.6 | ||||||||
其他 | 17 | 13.7 | ||||||||
Am | 52 | 11.6 | rrs-1401-A/G | 25 | 48.1 | |||||
rrs-514-A/C | 23 | 44.2 | ||||||||
其他 | 4 | 7.7 | ||||||||
Cm | 27 | 6.0 | rrs-1401-A/G | 27 | 100.0 | |||||
Km | 32 | 7.2 | rrs-1401-A/G | 27 | 84.4 | |||||
其他 | 5 | 15.6 | ||||||||
Eto | 57 | 12.8 | inhA-15-C/T | 48 | 84.2 | |||||
其他 | 9 | 15.8 | ||||||||
PAS | 32 | 7.2 | folC-43-I/T | 5 | 15.6 | |||||
thyA-75-H/N | 10 | 31.3 | ||||||||
其他 | 17 | 53.1 |
药品 | 突变类型 | L2基因型(378株) | L4基因型 (67株) | χ2值b | P值 | ||||
---|---|---|---|---|---|---|---|---|---|
突变株数 | L2.3型 (231株) | L2.2型 (140株) | χ2值a | P值 | |||||
INH | katG-315-S/T | 301(79.6) | 172(74.5) | 124(88.6) | 10.764 | 0.000 | 41(61.2) | 10.874 | 0.001 |
inhA-15-C/T | 23(6.1) | 19(8.2) | 4(2.9) | 4.319 | 0.038 | 4(6.0) | 0.001 | 0.971 | |
RFP | rpoB-450-S/L | 216(57.1) | 143(61.9) | 69(49.3) | 5.668 | 0.017 | 41(61.2) | 0.383 | 0.536 |
EMB | embB-306-M/V | 87(23.0) | 50(21.6) | 35(25.0) | 0.556 | 0.456 | 7(10.4) | 5.396 | 0.020 |
embB-306-M/I | 43(11.4) | 29(12.6) | 13(9.3) | 0.928 | 0.335 | 10(14.9) | 0.684 | 0.408 | |
Sm | rpsL-43-K/R | 191(50.5) | 137(59.3) | 53(37.9) | 16.053 | 0.000 | 7(10.4) | 37.021 | 0.000 |
rpsL-88-K/R | 44(11.6) | 23(9.9) | 18(12.9) | 0.746 | 0.388 | 3(4.5) | 3.091 | 0.079 | |
Ofx | gyrA-90-A/V | 36(9.5) | 25(10.8) | 10(7.1) | 1.381 | 0.240 | 3(4.5) | 1.812 | 0.178 |
gyrA-94-D/G | 34(9.0) | 18(7.8) | 16(11.4) | 1.385 | 0.239 | 3(4.5) | 1.523 | 0.217 | |
SLID | rrs-1401-A/G | 24(6.3) | 11(4.8) | 13(9.3) | 2.948 | 0.086 | 1(1.5) | 2.532 | 0.112 |
Eto | inhA-15-C/T | 41(10.8) | 36(15.6) | 5(3.6) | 12.797 | 0.000 | 7(10.4) | 0.009 | 0.923 |
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