Abstract:

Objective To analyze the influencing factors of medication adherence among patients with multidrug-resistant pulmonary tuberculosis (MDR-PTB) and to provide a basis for exploring and formulating diagnosis and treatment, management policies and measures for patients with MDR-PTB. Methods The cluster sampling method was used to collect the medical records and follow-up records of 120 newly diagnosed MDR-PTB patients who were diagnosed and treated and completed 24 months of follow-up at Henan Infectious Diseases Hospital during October 2015 to March 2017. A questionnaire survey on core knowledge of tuberculosis prevention was conducted by trained questionnaire surveyors to 120 newly diagnosed MDR-PTB patients, the valid withdrawal of the questionnaire was 120 with the withdrawal rate of 100.00%.The treatment compliance and its influencing factors were analyzed by unconditional dichotomous logistic regression analysis of univariate and multivariate. Results Among the 120 cases of newly diagnosed MDR-PTB, 85 cases had good medication adherence and 35 cases had medication adherence. Multivariate regression analysis showed that: poor family economic status (Wald χ ²=5.483, P=0.019, OR=6.27, 95%CI=2.51-13.92), adverse drug reactions (Wald χ ²=7.038, P=0.008,OR=4.73, 95%CI=1.95-10.17), poor awareness of core knowledge on tuberculosis prevention (Wald χ ²=4.621, P=0.032, OR=2.07, 95%CI=1.03-5.65) and self-medication (Wald χ ²=5.925, P=0.010, OR=2.45, 95%CI=1.92-7.01) were the main risk factors for treatment compliance. Conclusion Poor family economic status, adverse drug reactions, self-medication and poor awareness of core knowledge on tuberculosis prevention were the main risk factors for medication adherence, which can be used for reference in exploring and formulating MDR-PTB patients diagnosis and treatment, management policies and measures.

Key words: Tuberculosis, multidrug-resistant, Medication adherence, Risk factors, Factor analysis, statistical