Abstract:

A total of 77 patients with primary pulmonary tuberculosis complicated with cervical lymphatic tuberculosis admitted in Nanjing Integrated Traditional Chinese and Western Medicine Hospital from Mar. 2014 to Mar. 2018 were selected. All patients were diagnosed by imaging examinations, laboratory examinations and tuberculin tests and all met the inclusion criteria. They were divided into control group (n=32) and observation group (n=45) according to different treatment methods. The control group was treated with conventional western medicine (2H-R-Z-E/4H-R), while the observation group was treated with Neixiao Luoli slice on top of the control group treatment. The clinical effectiveness, sputum negative conversion rate, lesion absorption, change of inflammatory factors test results and adverse reactions were compared between the two groups. The total effective rate, sputum negative conversion rate, and obvious absorption rate of lesions in the observation group were 97.78% (44/45), 97.78% (44/45), and 80.00% (36/45) respectively, which were higher than those in the control group (81.25% (26/32), 75.00% (24/32), and 56.25% (18/32)) with statistically significant differences (χ ² values were 4.343, 9.400, 5.036, and P values were 0.037, 0.002, 0.002, respectively). After treatment, IL-6 and TNF-α levels in the observation group were (36.01±4.26) ng/L and (7.66±3.16) ng/L respectively, which were significantly lower than before treatment ((58.74±6.11) ng/L and (23.01±4.52) ng/L, t=20.471, P<0.001; t=18.671, P<0.001), and significantly lower than the control group ((43.21±5.22) ng/L and (12.12±3.96) ng/L, t=6.652, P<0.001; t=5.491, P<0.001). The incidence of adverse reactions was 42.22% in the observation group and 46.88% (15/32) in the control group, with no statistically significant difference between the two groups (χ ²=0.164, P=0.685). Our study shows that Neixiao Luoli slice combined with chemotherapy for the primary treatment of pulmonary tuberculosis complicated with cervical lymph node tuberculosis can effectively improve the immune function of patients, significantly reduce the level of inflammatory factors, and improve the clinical effectiveness.

Key words: Tuberculosis, pulmonary, Tuberculosis, lymph node, Drug therapy, combination, Drugs, Chinese herbal, Comparative effectiveness research