Abstract:

Objective To investigate the effectiveness and tolerance of treatment regimen which are 2H-R-E/10H-R and 2H-Z-E/10H-R for pregnancy combined with tuberculosis patients, as well as the influence of congenital malformation for newborns.Methods Bring 79 pregnancy cases were cured in Beijing Chest Hospital from September 1998 to December 2014 combined with initial treatment pulmonary tuberculosis at first 3months’ gestation into this study, and all cases got antituberculosis therapy after 3months’ gestation. All cases were randomly divided into A group and B group through random number table method. A group was 40 cases and they got 2H-R-E/10H-R. B group was 39 cases and they got 2H-Z-E/10H-R. There were 10 cases quit. Finally, A group was 35 cases and B group was 34 cases. Evaluating treatment effect of patients in two groups at the end of second and twelfth month through CT scan. Adverse drug reaction was evaluated through therapeutic process. Meanwhile, observe the congenital malformation conditions for newborns in two groups. All data were took in statistical treatment through SPSS 14.0 software and the count data was expressed as χ ² test. Finally, P<0.05 was considered statistically significant. Results Sixty-nine cases finished treatment course. The effective rate for group A and B at the end of second and twelfth month of treatment were 97.1%(34/35) and 94.1%(32/34) respectively. And the invalid rate were 2.9%(1/35) and 5.9%(2/34) respectively. There was no statistical significance(Fisher exact propability, P=0.614). The incidence of drug-related adverse reaction at the end of twelfth month of treatment was 14.3%(5/35) and 32.4%(11/34) for group A and B respectively. There was no statistical significance(χ ²=3.16, P=0.075). There was no aggravation for 69 cases from third month of pregnancy to the end of twelfth month of antituberculosis therapy. Newborns were followed up for 5months and all newborns did not get malformation and tuberculosis infection. Conclusion The curative effect of treatment course which were 2H-R-E/10H-R and 2H-Z-E/10H-R for pregnancy patients combined with tuberculosis was obvious and no difference. Patients could tolerate this treatment course and there was no congenital malformation for newborns. Therefore, all therapeutic schedule could be applied to clinical practice.

Key words: Tuberculosis, pulmonary, Pregnancy complication, infectious, Therapy, investigational, Program evaluation, Treatment outcome