Current situation and progress of cerebrospinal fluid-based laboratory tests in patients with tuberculous meningitis

doi:10.3969/j.issn.1000-6621.2018.03.020

Abstract

Abstract:

Tuberculous meningitis (TBM) is one of the most common extra-pulmonary tuberculosis (TB), accounting for about 1% among all types of TB cases. The death rate of TBM can reach 26.8%, while the death usually occurs in the first six months. Early diagnosis and treatment are the important factors to improve the prognosis of TBM. Clinically, the diagnosis of TBM is made based on a comprehensive analysis by evaluating the clinical features, cerebrospinal fluid (CSF) tests, cerebral imaging features and the evidences of extra-cranial TB. The results of CSF-based tests are the important diagnostic indicators for TBM diagnosis. Detection of Mycobacterium tuberculosis and its specific markers in cerebrospinal fluid is extremely helpful for TBM diagnosis.

Key words: Tuberculosis,meningeal, Diagnosis, Laboratory techniques and procedures, Review

Xue-lian LI,Meng-qiu GAO. Current situation and progress of cerebrospinal fluid-based laboratory tests in patients with tuberculous meningitis[J]. Chinese Journal of Antituberculosis, 2018, 40(3): 320-324. doi: 10.3969/j.issn.1000-6621.2018.03.020

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