Abstract: Objective  To evaluate the tuberculosis epidemic situation and the effect of control program in Quanzhou city.  Methods  This is a retrospective survey, we made the comparison of new smear positive pulmonary tuberculosis (PTB) registration rate and treatment outcome between the first decade (1992—2011) and second decade (2002—2011) of implementation of world bank tuberculosis control project. A total of 30491 cases were registered. We made the drug susceptibility test for 3532 new culture-positive outpatient and inpatient registered between 1991 and 2005, taking every 3 years as a phase, and analyzed the resistance rates of the 5 phases.  Results  Between 1992 and 2001, a total of 7016 cases of new smear-positive tuberculosis were registered with the average registration rate of 11.4/100000（7016/630050）. In contrast, after the project implementation between 2002 and 2011, 23475 cases were registered with the registration rate of 30.37/100000（23475/772870）which increased 2.73 times compared with before the project. The male registration rate was 2.75 times higher than that of female. Patients aged between 15-54 accounted for 74.19%（22622/304910）；majority of patients were farmers, accounting for 50.57% (15419/30491); geographical distributed mainly along the coast, accounting for 72.29% (22958/30491), the cure rate was 86.61% (26409/30491). Within the 15 years, the initial drug resistance rate decreased from 27.66% (135/488) in 1991-1993 to 10.62% (77/725) in 2003-2005 with the decreasing rate of 61.61%［(27.66-10.62)/27.66］. Conclusion  The control effect of tuberculosis is remarkable. And in the future we should target the young adults and floating population, improve the quality of DOTS and control the generation of drug resistant TB.

Key words: Tuberculosis, pulmonary/epidemiology, Tuberculosis, pulmonary/prevention &, control, Drug resistance, bacterial, Quanzhou city