Abstract: Objective To investigate the curative effect of ginseng polysaccharide on adjuvant therapy of type 2 diabetes combined with pulmonary tuberculosis(PTB). Methods One hundred and twenty outpatients with diabetes combined with PTB notified in Shantou Institute of Tuberculosis Control and Prevention from January to December,2011 were the study targets. The diagnosis of TB was accord with the standard of Clinical Practice Guidelines for Tuberculosis, and the diagnosis of type 2 diabetes was accord with the standard of China Guideline for Diabetes issued in 2009 by Chinese Diabetes Society. One hundred and twenty patients were randomly divided into experimental group(62 cases)and control group(58 cases)based on oddeven notified number. Routine antiTB and glucoselowering treatment were applied in control group(180days),while ginseng polysaccharide was given(12mg intramuscular injection every other day for 180days)to experimental group besides the routine treatment. The short term effect and the change of T cell subset of the two groups were compared. SPSS 13.0 software was used for data analysis,ttest was used for quantitative data andχ² test was applied for rate comparison. P<0.05 was set as the standard of statistical significance. Results The sputum conversion rate of experimental group was 95.2%(59/62), which was significantly higher than that of the control group(79.3%,46/58)(χ²=6.88, P<0.01). The effective rate of experimental group(96.8%,60/62)was also significantly higher than control group(75.9%, 44/58)(χ²=11.34, P<0.01). From peripheral blood testing,the proportions of CD3⁺ T cells in patients in experimental group was(50.0±10.42)% after treatment and(34.89±7.26)%before treatment,and the proportion in patients in control group was(37.46±8.96)%before treatment, tvalues were 9.36 and 7.04 respectively compared with the latter two,and both P value were less than 0.01. The proportions of CD4⁺ T cell in experimental group were(34.88±9.96)% after treatment and(25.89±8.68)% before treatment,while that in control group after treatment was(25.64±9.68)% after treatment, tvalues were 5.38 and 5.11 compared with the latter two with P<0.01. The ratios of CD4/CD8 were 1.58±0.78,1.15±0.45 and 1.20±0.62 respectively,and the tvalues were 3.76 and 2.94 compared with the latter two with  P<0.01. The proportions of CD8⁺T cell were(18.50±7.22)%,(24.76±9.85)%and(23.86±8.92)%respectively,and the tvalues were 4.03 and 3.63 compared with the latter two with P<0.01. Conclusion The sputum conversion rate,effective rate and cellular immune function were clearly improved by ginseng polysaccharide on diabetes combined with PTB.

Key words: Tuberculosis, pulmonary, Diabetes mellitus, type 2, Panax, Polysaccharides