The relationship between the adaptor molecule caspase recruitment domain-containing protein 9 and anti-tuberculosis immunity

Abstract

Abstract: Tuberculosis(TB) is a chronic infectious disease, globally 1.7 million people die from TB annually.The number of TB patients in China ranks the second in the world. China is one of the countries with high prevalence of multi-drug resistance TB (MDR-TB). The number of TB deaths exceeds the sum of the number of deaths caused by other infectious diseases. Therefore, the development of effective anti-TB drugs and new vaccines is imminent. This requires the in-depth understanding of the interaction mechanism between the host and Mtb, and the internal signaling mechanisms and the key molecules of antigen presenting cell(APC). When the pathogen-associated molecular patterns(PAMPs) of Mtb is recognized by pattern recognition receptors (PRRs), the signal is transmitted to the adaptor molecule which starts the downstream signaling cascade reaction, induces innate immune cells to synthesize cytokines, and activates the host immune mechanisms. This review briefly elaborated the correlation between caspase recruitment domain-containing protein 9 (CARD9) and anti-TB immunity, and provided a reference for the TB treatment and the development of vaccine.

Key words: Tuberculosis/immunology, CARD signaling adaptor proteins

SUN Lei, ZHENG Jin-hui，WANG Cui, FEI Si-ping，ZHAO Zhuo. The relationship between the adaptor molecule caspase recruitment domain-containing protein 9 and anti-tuberculosis immunity[J]. Chinese Journal of Antituberculosis, 2013, 35(3): 204-206.

References

［1］Small PM.Tuberculosis: a new vision for the 21st century.Kekkaku,2009,84（11）:721-726.

［2］Janeway CA Jr,Medzhitov R. Innate immune recognition(Review）. Annu Rev Immunol,2002,20:197-216.

［3］Hsu YM,Zhang Y,You Y,et al.The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol,2007,8（2）:198-205.

［4］Dorhoi A, Desel C, Yeremeev V,et al.The adaptor molecule CARD9 is essential for tuberculosis control. J Exp Med, 2010,207（4）:777-792.

［5］Bertin J, Guo Y, Wang L, et al.CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. J Biol Chem,2000,275（52）:41082-41086.

［6］Hara H, Ishihara C, Takeuchi A, et al. The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol, 2007,8(6):619-629.

［7］Marakalala MJ,Graham LM,Brown GD. The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections. Clin Dev Immunol, 2010,2010: 567571.

［8］Ishii KJ, Koyama S, Nakagawa A, et al.Host innate immune receptors and beyond:making sense of microbial infections.Cell Host Microbe,2008,3(6):352-363.

［9］Koziol-Montewka M, Kolodziejek A, Oles J. Study on myeloperoxidase role in antituberculous defense in the context of cytokine activation.Inflammation, 2004,28(2):53-58.

［10］Ueda Y, Cain DW, Kuraoka M, et al. IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia. J Immunol, 2009,182(10):6477-6484.

［11］Chakravarty SD, Zhu G, Tsai MC, et al. Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs.Infect Immun,2008,76(3):916-926.

［12］Gross O, Gewies A, Finger K,et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.Nature,2006,442(7103):651-656.

［13］De Filippo K, Henderson RB, Laschinger M, et al. Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways.J Immunol,2008,180(6):4308-4315.

［14］Schoenen H, Bodendorfer B, Hitchens K,et al. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol, 2010,184(6):2756-2760.

［15］Werninghaus K, Babiak A, Gross O,et al. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J Exp Med, 2009,206(1):89-97.

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