Abstract: Objective To analyze and evaluate the implementation effect of global fund multi-drug resistant tuberculosis (MDR-TB) project, in order to provide reference for MDR-TB control work in Guangdong province. Methods Monthly and quarterly reports are all collected for retrospective analysis from Oct.2006 to Dec.2010. Results By the end of Nov.2012, a total of 12 165 MDR-TB suspects were screened, among which 12 125 cases received sputum culture, 8633 suspect cases performed drug susceptibility test (DST). 1170 MDR-TB patients were confirmed and 488 cases were recruited for treatment. A total of 221 MDR-TB cases included in treatment for 2 years, 99 cases were cured, and 5 cases completed treatment. The treatment success rate was 47.06%（104/221）. Conclusion With the implementation of the MDR-TB project, we established the MDR-TB diagnosis, treatment and management model. The standard treatment regimen as the main strategy is feasible.

Key words: Tuberculosis, pulmonary/prevention &, control, Drug resistance, multiple, bacterial, Health plan implementation, Guangdong province