Abstract: Objective To explore the early warning model of multidrug resistant tuberculosis suit for Guangdong features providing Guangdong province even nationwide with scientific and reliable theory foundation for the MDR-TB control and the implementation of national 10 years plan.Methods Establish the differential equation based on cybernetic theory and the assessment of MDR-TB mortality,detection rate and cure rate though weighted mean method.Results Build the MDR-TB transmission dynamical model with the threshold value of stimulated or derived R0 from real parameter.Conclusion The establishing of warning model of MDR-TB and the indicator adjusting need sophisticated drug resistant monitoring data.As a trying step to MDR-TB warning model,this research did find some clues for the improvement of national MDR-TB control.

Key words: Tuberculosis,pulmonary/prevention &, control, Tuberculosis,multidrug-resistant/prevention &, control, Guangdong province