Abstract: Objective To investigate the clinical features and the Methods of diagnosis and treatment for multiple intracranial tuberculomas.  Methods 13 patients with multiple intracranial tuberculomas were retrospectively analyzed from January 2004 to December 2007 in Shandong Chest Hospital.  Results The clinical presentations mostly consisted of headache(11/13), fever (10/11), vomiting(7/11) and increased intracranial pressure (8/13). Cell count from cerebral spinal fluid(CSF) was high in 11 cases. Extracranial tuberculosis were combined in 10 cases. Magnetic resonance imaging(MRI) showed iso-intense signal on T1-weighted imaging and hypo-intense signal on T2-weighted imaging. Histopathologic examination revealed tuberculosis granulomatous inflammation in 3 cases. Using comprehensive therapy including intensive anti-tuberculosis regimen, hormone and intrathecal injection with drugs, efficacy was satisfactory.  Conclusion Multiple intracranial tuberculomas is a special type of intracranial tuberculosis. Combination withits clinical,manifestation radiological features and CSF result, clinical diagnosis is helpful to be established. Comprehensive therapy including the intensive anti-tuberculosis regimen, hormone and intrathecal injection with drugs is recommended.

Key words: tuberculosis,intracranial/diagnosis, tuberculoma,intracranial/drug therapy