Abstract: Objective To evaluate the sensitivity and specificity of interferon-gamma (IFN-γ) quantitative detection kit (TB-IGRA, Beijing Wantai Biological Pharmacy Corporation Ltd.) for the diagnosis of tuberculosis (TB).  Methods We detected the serum specimens from 319 patients with pulmonary TB, 23 patients with extrapulmonary TB, 39 patients with non-TB lung disease and 104 healthy people with TB-IGRA and QuantiFERON-TB GOLD in tube (QFT-GIT, Cellestis, Australia) simultaneously, and compared their Results .  Results The sensitivities of TB-IGRA for TB and extrapulmonary TB were 90.9% and 78.3%, respectively, and it’s specificity was 76.9%. The sensitivities of QFT-GIT for TB and extrapulmonary TB were 88.4% and 78.3%, respectively, and it’s specificity was 80.4%. There was no significant difference between these two kits. Conclusion TB-IGRA is a highly sensitive and specific kit in the diagnosis of TB, and it can be used in the accessory diagnosis of tuberculosis, especially extrapulmonary tuberculosis.

Key words: tuberculosis/diagnosis, Mycobacterium tuberculosis, interferon type Ⅱ, reagent kits,diagnostic, sensitity and specificity