Abstract: Objective  To estimate of cost-effect on TB control and prevention in Gansu province.  Methods  to design the questionnaire of all levels in Gansu province,TB workers in 101 TB institutions including province，city and county level  filled  the questionnaires by making use of TB information materials from 2001 to 2009,to set up material data by Epidata and to have an analyseis  and statistic by Excel and SPSS 17.0.  Results  There are 153 718 active TB cases registered by the whole province in Gansu,of whom 1056 died of TB,there are 76 801 smear positive TB cases successfully cured,and 66 720 smear negative TB cases successfully cured.It is estimated that 38 429 TB cases will die of TB without cure，smear positive TB cases successfully cured，37 373 TB cases avoided  been dead due to reagular cure, 646 802 people avoided been infectious, 64 680 cases avoided to take place, it cost about 0.18 billion RMB yuan to control and prevent TB in our province, about 44 million  RMB yuan was saved in hospital expenditures, the total of about 6.83 billion RMB Yuan social overall cost was saved.It is estimated that investment of 198.29 can save a DALY, we can output 37.86 RMB Yuan in finance if we invest the cost of one RMB Yuan from 2001 to 2009.  Conclusion  TB control and prevention has made great contritution for decreasing TB epedimic situation and improving economic development.

Key words: Tuberculosis,pulmonary/prevention &, control, Tuberculosis,pulmonary/economics, Cost-benefit analysis, Gansu province