Abstract: Objective To understand the epidemiological trends and features of PTB patients complicated with diabetes(TB-DM) in Guangzhou in order to provide evidence base for TB control strategies formulation.  Methods Information of PTB patients registered from 2004 to 2008 in Yuexiu, Liwang, Haizhu and Tianhe district were analyzed.  Results The total number of TB-DM in these four districts were 1047 from 2004 to 2008, accounting for 6.2% of total PTB patients over the same periods, the 5-year average annual registration rate is 6.22/100000, no significant changes within 5 years（P>0.05）. Male and female TB-DM accounted for 6.5% and 5.3% of PTB patients of same gender respectively(P<0.01). The age of TB-DM ranged from 19 to 91 with a median of 59 years old, majority was middle-aged and elderly patients over 40 years old. Among TB-DM patients, 632 (60.4%)cases were smear positive,415 cases smear negative (39.6%), 527 cases with cavity 527 (50.3%). The proportion of patients with smear positive result and cavity in TB-DM cases were both significantly higher than tuberculosis cases without diabetes (P<0.01). Patients discovery were mainly by outpatient attendance due to suspected symptoms, accounting for 89.2%.  Conclusion s The TB-DM incidence is relatively high, and mainly in middle-aged and elderly people, proportions of both smear positive and with cavity are high. All of these bring difficulties to TB control therefore there is a need to strengthen TB control work in this population.

Key words: tuberculosis,pulmonary/epidemiology, diabeles mellitus, Guangzhou City