Clinical utility of an in-house interferon-γ Elispot assay for the diagnosis of active tuberculosis

Abstract

Abstract: Objective To appraise the clinical utility of an in-house interferon-γ Elispot assay for the diagnosis of active tuberculosis.Methods A in-house Elispot assay was used to determine Mycobacterium tuberculosis antigen-specific IFN-γ production in 1154 patients with active tuberculosis,52 case controls with non-tuberculosis lung diseases,422 healthy controls and 384 close contacts with newly diagnosed active tuberculosis patients.PPD skin test was used in parallel with Elispot in some healthy controls and clos...

Key words: tuberculosis/diagnosis, interferon-γ, immunoenzyme techniques

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CHEN Xin-Chun, LIAO Ming-Feng, ZHU Xiu-Yun, ZHANG Jie-Yun, CHEN Tao, ZHANG Ming-Xia, GU Mei-Hong, ZHANG Fan, YU Wei-Ye, ZHOU Bo-Ping. Clinical utility of an in-house interferon-γ Elispot assay for the diagnosis of active tuberculosis[J]. Chinese Journal of Antituberculosis, 2010, 32(11): 747-751.

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Clinical utility of an in-house interferon-γ Elispot assay for the diagnosis of active tuberculosis

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