Abstract: ObjectiveTo study clinical features and improve level of diagnosis and treatment for nontuberculous mycobacteria(NTM) lung disease. Methods50 patients with NTM lung disease confirmed by culture with Lowestein-Jensen,medium in our hospital between August 1999 and March 2006 were carried out drug susceptibility test, and their clinical manifestation and therapeutic effects were analized.Results The strains isolated from patients with NTM lung disease were resistant to the first line anti-tuberculosis drugs in various degree with highest resistant rate to isoniazid(H) and streptomycin(S) and lower rate to Amikacin(Ak) and Kanamycin(Km).ConclusionsNTM lung diseaseshould be conformed by positive culture and strain identification. Early reasonable chemotherapy may offer satisfied efficacy.

Key words: Mycobacterium infections, Mycobacterium, Drug resistance,bacterial