Abstract: Objective To understand the distribution and influential factors of patients with drug resistance among TB patients in our hospital. Methods1125 patients with sputum culture positive from 4195 patients with pulmonary tuberculosis from Aug.2002 to Aug.2008 were divided into initial drug resistance group, acquired drug resistance group, drug resistance group, and multi-drug resistance group according to different standards. The data of resistant test of four anti-TB drug for these patients was analyzed with clinical epidemiology method. Results1. There were 566(50.3%) cases in the drug resistance group and 135(12.0%) cases in the MDR-TB group(χ²=13.457, P<0.05) with statistically significant difference in resistance rate of the two groups.2. Age distribution is mainly the elderly, 3. Of any drug, the order of accumulated drug resistance is S>H>R>E.4. High concentration of levofloxacin resistance is 32.5%, and low concentrafion is 9.0%.Conclusions The drug-resistance rate and multi-drug resistance tate aftuberculosis is still high, further analysis is needed. The rate of drug resistance of high concentration of Levofloxacin is low, which would have deep effect on the therapy of MDR-TB.

Key words: pulmonary tuberculosis/drug therapy, drug resistance, bacterial, Beijing city