Abstract: Objective To analyze the factors of MDR-TB from clinical point of view and the out- come of individualized regimen for different patterns of drug resistance(MDR,XDR and TDR). Methods Retrospective study was adopted to analyze the risk of multi-drug resistance and clinical response for 104 MDR-TB cases,which had both laboratory DST Results and 24-month follow-up outcome.Chi-square test was used for statistic analysis between each group.Results (1)The cau- ses of MDR were mainly focused on irregular use of anti-TB drugs and primary drug resistance and resistance after regular treatment,which respectively contribute 31.7%,27.9% and 20.2% of all the MDR reasons analyzed(with the total of 79.8%).(2)The sputum conversion rate at the end of therapeutic course in the group of MDR-TB,XDR-TB and TDR-TB were 52.20%,40.9% and 0% respectively.The treatment outcome did not show statistically difference between MDR and XDR (P>0.05).However,there was significant differences between TDR and MDR(P<0.01),TDR and XDR for MDR(P<0.05).Conclusions Guideline should be developed to completely cure the new PTB cases and to prevent MDR,XDR and TDR gradually.Early diagnosis and timely treat- ment to MDR-TB patients is essential to increase the cure rate of MDR.

Key words: Pulmonary tuberculosis, Multi-drug resistance/clinical analysis