Abstract: Objective To explore the liver injury due to the anti-TB treatment among the HBVDNA,HBVM positive TB. Methods Pulmonary tuberculosis patients with HBVM(Hepatitis B virus Marker) positive and HBVDNA positive were recruited in experimental group A,those with HBVM positive but HBVDNA negative were recruited in experimental group B,those with HBVM negative were recruited as control group C,The prevalence rate of liver injury and withdrawal of anti-tuberculosis drugs and the relationship between HBVDNA level and those rates were observed. Results The prevalent rate of liver injury was statistically different in any of the two groups(P<0.01);the rate of withdrawal of group A was higher than other two groups(P<0.01),while Group B and group C did not have the difference on the withdrawal(P>0.05);there were no relationship between HBVDNA level and the prevalent rates of liver injury and withdrawal(P>0.05) in group A. Conclusion Attention should be paid to the liver injury of the pulmonary tuberculosis with HBVM positive and HBVDNA Those with HBVDNA negative could been treated by short-course chemotherapy.Despite the HBVDNA level,those with HBVDNA positive should been careful treated by shortcourse chemotherapy.

Key words: Pulmonary,tuberculosis, Hepatitis B virus, DNA,virus