Abstract: ObjectiveTo determine the expression and significance of heat shock protein 70(HSP70) in pulmonary tuberculosis(TB) and explore the relationship between HSP70 with TB. Methods The method of sandwich ELISA was used to detect the expression of HSP70 in the blood plasma from 32 pulmonary TB patients which was compared with 25 stable pulmonary TB patients and 25 healthy controls. Results The expression of HSP70 in the blood plasma in active pulmonary TB patients,stable pulmonary TB patients and healthy controls was(7.5±1.3) ng/ml,(5.5±1.7)ng/ml and(5.3±0.8)ng/ml respectively.Active pulmonary TB patients had higher level of HSP70 expression in blood plasma compared with healthy controls and stable pulmonary TB patients(P<0.01).There was no significant difference between stable pulmonary TB patients and healthy controls(P>0.05). Conclusions There is over-expression of HSP70 in active pulmonary TB patients and it could be took as one of the diagnosis marks of active pulmonary TB.

Key words: Pulmonary tuberculosis/blood, Heat shock protein 70