Abstract: Objective To survey and analyse the treatment compliance of fixed-dose combination(FDC),so as to provide evidences for expending use FDC nationwide. Methods Nine hundred and sixty-six primary smear positive pulmonary tuberculosis cases registered in 17 counties TB institutions from 4 provinces were randomly divided into experiment and control groups.Compared compliance difference with uniform questionnaires,and analysed compliance changes with time throughout the treatment. Results Nine hundred and sixty-one cases were surveyed at the beginning,899(93.5%)preferred receiving treatment.There was significant difference on the percentage who prefer had drugs per day between experiment(86.8%)and control group(42.1%)(P<0.01).At the end of intensive phase,261(28.3%)cases perceived difficulty with the treatment;213(23.1%)cases thought that were the doctors who lead to the insist of treatment.At the end of treatment,only 138 cases(15.5%)thought that were the doctors who lead to the insist of treatment. Conclusion The compliance of FDC was better than contro1 group.It might increase the compliance when decreasing the number of tablets and should expend used on TB control.The effect of TB doctors decreased through the treatment.More intention should be paid in intense phase.

Key words: Pulmonary tuberculosis/drug therapy, Fixed-dose combination