Abstract: Objective To study the risk factors,clinical character and means of diagnosis and treatment of secondary fungal infection of pulmonary tuberculosis cases. Method The information of 74 cases of fungi infection confirmed by culture and identification in 5 hospitals,Shandong province from January 2002 to September 2004 were collected and analysed. Results The distribution of fungi in 74 cases were Candida albicans(70.3%),Glabrata(12.2%),、C.tropicalis(6.8%)and candida krusei (4.1 %).Drug resistance rates of Amphotericin B,Fluorocytosine,Fluconazole,Itraconazole,Ketoconazole were mensurated by ROSCO paper disk diffusion.The antifungal susceptibility to Candida albicails was better and the resistance rates of candida krusei was higher. Conclusion It is common that fungal infection occurredin pulmonary tubetchlosis cases.Standardized application of antibiotic and hormone should be strengthened to reduce the rate of fungal infection and their resistance rates,which will be contribute to tuberculosis control and reduce death rate.

Key words: Pulmonary tuberculosis/complications, Lung diseases,fungal