Abstract: Objective To study the diagnostic value of tuberculosis protein chip,acid-fast smear and tuberculin purified protein derivative(PPD) in pulmonary tuberculosis. Methods 45 patients with active pulmonary tuberculosis,30 patients with respiratory system diseases other than tuberculosis as control were tested by tuberculosis protein chips,acid-fast smear and PPD,respectively.The Results were compared with each other. Results The examination sensitivitives of tuberculosis protein chip,PPD and acid-fast smear were 66.7%,44.4%,22.2% respectively,and the specificity was 93.3%,84.6%,100 %.The detection rate of combined method was obviously higher than that of the single test,and the positive rates increased by 88.9%.But he specificity remain 80%. Conclusion Tuberculosis protein chip may be used To test Mycobacterium tuberculosis quickly and accurately.The combination had an increased detection rate in detecting pulmonary tuberculosis and remain a higher specificity.

Key words: Pulmonary tuberculosis/diagnosis, Protein sequence analysis