The mensuration and clinical values of the soluble Fas in tuberculosis patitents

Abstract

Abstract: Objective To determine the values and clinical significance of level of soluble Fas(sFas) in tuberculosis patitents . Methods The content of the sFas in the plasmas and the supernatant of peripheral blood mononuclear cells (PBMC) cultures of 63 tuberculosis patients were examined with enzyme-linked immuno- sorbent assay (ELISA) . ResultsThe levels of the sFas in both the plasmas and supernatant of PBMC cultures in tuberculosis patients were significantly higher than in controls (6.672.05/2.210.54;P＜0.01;46.6412.44/15.973.51,P＜0.001);The levels of the sFas in the plasmas and supernatant of PBMC cultures in patients with cavity were significantly higher than that in patients without cavity (7.981.41/5.131.25,P＜0.01;55.9418.52/35.7311.44,P＜0.01). The levels of the sFas in patients who had been treated more than one month were significatively higher than that in the patients who had not been treated (6.831.39/5.681.23 P＜0.01;52.3714.55/39.436.97,P＜0.01). ConclusionsThe disregulation of the sFas maybe a attribution factor to the occur of tuberculosis. The variety of the sFas in the patients with tuberculosis could be used to forecast the status and prognosis.

Key words: sFas, Pulmonary tuberculosis, Enzyme-linked immunosorbent assay(ELISA)

Liu Jiahong, Wang Yingnian, Gong Xitao, et al.. The mensuration and clinical values of the soluble Fas in tuberculosis patitents[J]. Chinese Journal of Antituberculosis, 2005, 27(4): 224-226.

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