Abstract: Objective To investigate efficacy of preventive chemotherapy treatment and management of administration for tuberculosis-infected students of university. Methods Members of Red Cross, doctors from hospital of university and district tuberculosis center were combined and shared out the work and help one another, including extensive health promotion PPD testing and management of preventive chemotherapy. Preventive chemotherapy was given to new students with over 15 mm PPD testing reactors based their consent. Placebo-controlled study was adopted and incidence rate was investigated during follow-up 4 years. Rifapentine and isoniazid intermittent regimen was selected twice weekly for 3 months, total 25 times. Results There were 3 713 students enrolled, 1948 and 1765 students of which were selected as treated and placebo groups respectively. Complete treatment rate was 90%. Side effects rate was 3.3% and stopping drug treatment rate 0.98%. There were 5 cases, 64.17/100,000 and 18 cases, 254.96/100,000 occurred in treated and placebo groups during 4 years follow-up respectively. It showed 74.8% protection against subsequent tuberculosis. Conclusion Previntive treatment with Rifapentine and Isoniazid twice weekly for 3 months is effectiveness, safety and feasibility in the students of university.

Key words: Tuberculosis/prevention and control, Preventive chemotherapy treatment.