Abstract: Objective To determine the significance of interventional therapy on cavitary pulmonary MDR-TB.Methods Study the inhibitory effects on 36 cultured drug-resistant TB strains using increased concentration of anti-tuberculosis drugs,and compare the clinical effect of treaditional anti-TB treatment vs.bronchoscope-assisted interventional therapy on cavitary pulmonary MDR-TB.Randomly selected 180 adult hospitalized patients with cavitary pulmonary MDR-TB and received 3DLOZA/18DLOZ treatment.The therapeutic group consists of 86 patients treated with both traditional and the bronchoscope-assisted interventional antituberculosis drug therapy and had completed.Results Increased concentration of antituberculosis can effectively control growth of drug-resistant tuberculosis.However,the dosage needed could be far more less than the concentration of the antituberculosis jelly interventional therapy.For the sputum negative rate,the therapy group (88.4%) was higher than the controlled group (70.0%).The cavitive closing rate was higher in therapy group (43.0%) than the controlled group (20.0%) too.In addition,more clinically improvement had been shown in the therapy group than the controlled group.Upon observation,the therapeutic effect was much better on single,caseous cavity than on multiple,fibrous cavity.There had not been any observed adverse reaction in the process of interventional therapy.Conclusion Super-drug-resistant TB can be more effectively controlled by higher dose of antituberculosis drugs.Bronchoscope-assisted interventional antiphthisic therapy is an safe and effective way to treat refractory cavitary pulmonary MDR-TB,provided the significant effect on cleaning,closing of the cavity as well as turning sputum negative.Worthwhile,the clinical application should be approached extensively.

Key words: Pulmonary tuberculosis/chemotherapy