Abstract: Objective To evaluate the effects of antitubercu lo sis drugs in hematological system.Methods The clinical data of 115 pulmonary patients with the abnormality in hematological system from Jan.199 6 to Jun.2004,were reviewed retrospectively.Results In 4812 tuberculosis cases,the abnormality in hematol ogical system were 115 (2.4%),aleucocytosis were most common existed (44.4%),th e second were pancytopenia (22.6%) and thrombocytopenia with hypolekocytosis (10.4%).aplastic anemia,HA and SMF were seldom seen.Conclusion Almost all the antituberculosis drugs can cause abno rmality of hematological system.Rifomycins were most common next were aldinamide and isoniazide.It can cause a formed elements to change in blood.A nd cause the abnormality of whole blood,and death in serious patients cause.So it should be on guard against.

Key words: Antituberculosis drugs, Hematological system, Abnormal ity