Abstract: Objective To study the correlation between serum immunosuppressive acidic proteins (IAP) and T lymphocyte subsets in patie nts with pulmonary tuberculosis(TB).Methods The levels of IAP were detected by agar diffusion assay, and T lymphocyte subsets detected by the technique of alkaline phosphatase and anti-alkaline pho sphatase (APAAP) in 122 patients suffered from pulmonary TB and 45 healthy indiv iduals.Results The level of IAP was higher,and the expression of CD₃,CD₄ and the ratio of CD₄/CD₈ were lower in patien t group and both of those two indicators showed a siginificant difference with t hat control group(P<0.05).The changes of them were more obvious in progressi ve stage than that in stable and improving stages, respectively (P<0.05).The re was a negative correlation between IAP level and the expression of CD₃,CD₄ and the ratio of CD₄/CD₈(P<0.05).There was a positive correlation betw een CD₈ expression (P<0.05).Conclusion The Results indicate the change of IAP level and T lymphocyte subset may be rela ted with the severity and prognosis of pulmonary TB patient.

Key words: Tuberculosis,pulmonary/blood, Immunosuppressive acidi c protein, T-lymphocyte subsets