Abstract: Objective To determine the effect of Wu-Zhi Cap su les in preventing and treating liver damage caused by anti-tuberculosis drugs.Methods 179 initially-treated pulmonary tuberculosis patients who received the regimen of 2HRZS(E)/4～10HR were randomly separated into 2 grou ps:Observe group,96 cases,supplemented with Wu-Zhi Capsules for six mouths and Control group,83 cases,received glucurolactone.Results There were 7 cases who had liver damage in observe grou p (7.3%),5 cases with HBsAg positive (11.4%);There were 32 cases who had liver damage in control group (38.6%),20 cases with HBsAg positive (52.6%).There wa s signific ant difference between the 2 groups (P<0.01).HBsAg,HBeAg positive patients were more likely to have liver damage in anti-tuberculosis treatment.Conclusion Wu-Zhi capsules is effective in preventing and trea ting liver damage caused by anti-tuberculosis drugs,HBsAg,HBeAg positive patien ts’ liver function should be monitored in the early period of anti-tuberculosis treatment.

Key words: Tuberculosis,pulmonary, Wu-Zhi Capsules, Drug adverse effect