Abstract: Objective To investigate and compare the infecton of extended spectrum beta lactamases (ESBLs) producing strains and their antibiotic resistance in patients with pulmonary tuberculosis and non pulmonary tuberculosis.Methods Inhi bitor potentioted disc diffusion test was used to determine the ESBLs producing strains and the Sceptor Pette system was used to test antibiotic susceptibility to 21 kinds of antibiotics applied clinically.Results The positive rate of ESBLs in Klebsiella Pneumoniae and Escherichia Coli was 39% and 78% in patients,which should that the rate in pulmonary was higher than the rate in non pulmonary tuberculosis.The later was only 21% and 53%,respectively.These ESBLs producing strains had hihger resistance rate to the 1st and the 2nd generation of Cephalosporin’s,Penicillin’s,Tetracycline’s,Trime/sul and Quinollne’s,while only 41% to 63% antibiotic susceptibility rate to Aztreonam and the 3nd generation of Cephalosporin’s,but these strains had higher sensitivit to Amino glycosides.Conclusion ESBLs palys an important role in the mechanism of Gram negative bacterium antibiotics resistance to Cephalosporin’s (3rd generation) and monocycle beta lactam antibiotics.Both the detecting of ESBLs producing strains and the testing of antibiotic susceptibility should be highly emphasized.

Key words: Tuberculosis,pulmonary, ESBLs, Antibiotc sensitivity