Abstract: Objective To investigate the effect of regimen of 2H₃R₃Z₃S₃(E₃)/4H₃R₃ on the liver function of the pulmonary tuberculosis patients accompanied with positive markers of HBsAg,HBeAb,and HBcAb.Methods From December 1994 to December 1998,the liver function of the pulmonary tuberculosis patients with positive markers of HBsAg,HBeAg,and HBcAb (group Ⅰ) who were given the treatment of regimen of 2H₃R₃Z₃S₃(E₃)/4H₃R₃,was retrospectively analyzed.Simultaneously,the Results have been compared with those of negative markers of viral hepatitis patients (group Ⅱ).Results The incidence of liver damage in group Ⅰ was 15.6%,higher than that in the group Ⅱ (12.0%),but no significant difference was found between the two groups (P＞0.05).Conclusion The regimen of 2H₃R₃Z₃S₃(E₃)/4H₃R₃ had a slight damage to the liver function of the pulmonary tuberculosis patients with positive marker of HBsAg,HBeAb,and HBcAb and is worthy spreading.