Chinese Journal of Antituberculosis ›› 2022, Vol. 44 ›› Issue (11): 1199-1204.doi: 10.19982/j.issn.1000-6621.20220250
• Review Articles • Previous Articles Next Articles
Zhang Rui, Liu Yanping, Qian Jun, Fang Qianglin, Yang Chongguang()
Received:
2022-07-07
Online:
2022-11-10
Published:
2022-11-03
Supported by:
CLC Number:
Zhang Rui, Liu Yanping, Qian Jun, Fang Qianglin, Yang Chongguang. Updates on the application of whole-genome sequencing for within-host heterogeneity of Mycobacterium tuberculosis[J]. Chinese Journal of Antituberculosis, 2022, 44(11): 1199-1204. doi: 10.19982/j.issn.1000-6621.20220250
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URL: http://www.zgflzz.cn/EN/10.19982/j.issn.1000-6621.20220250
方法 | 分析对象 | 结果识别 | 微进化 | 多重/混合感染 | 参考文献 |
---|---|---|---|---|---|
噬菌体分型 | 噬菌体菌落裂解 | 对特定结核分枝杆菌噬菌体的易感性 | 否 | 对多个不同的结核分枝杆菌噬菌体具有易感性 | [ |
IS6110限制性片段长度多态性分型 | 特异性的插入序列 | 限制性内切酶带杂交指纹图谱 | 1~2个条带差异 | > 2个条带 | [ |
1~3个条带差异 | > 3个条带 | [ | |||
间隔区寡核苷酸分型 | 直接重复区 | 直接重复区序列杂交指纹图谱 | 否 | 多个基因型认定为混合感染 | [ |
结核分枝杆菌散在重复单元-可变数目串联重复序列 | 特异性重复序列 | 基于PCR的拷贝数的差异 | <2个位点出现多个条带 | ≥2个位点出现多个条带 | [5, 29-32] |
二代测序 | 全基因组多态性 | 异质性SNP | 否 | ≥20个SNP或11~19个SNP且异质性SNP占比>1.5% | [ |
≤80个SNP | >80个SNP | [ | |||
≤140个SNP | >140个SNP | [ | |||
0~5个SNP | 757~833个SNP | [ | |||
2~15个SNP | 否 | [ | |||
每个基因组0.5个SNP/年 | 否 | [ | |||
生物信息软件/统计算法 | 否 | 不同进化路径等 | [ |
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