Chinese Journal of Antituberculosis ›› 2022, Vol. 44 ›› Issue (10): 1079-1084.doi: 10.19982/j.issn.1000-6621.20220194
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Wang Li, Yang Enzhuo, Sha Wei(), Shen Hongbo
Received:
2022-05-23
Online:
2022-10-10
Published:
2022-09-30
Contact:
Sha Wei
E-mail:shfksw@126.com
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Wang Li, Yang Enzhuo, Sha Wei, Shen Hongbo. Research progress in immunotherapy of tuberculosis[J]. Chinese Journal of Antituberculosis, 2022, 44(10): 1079-1084. doi: 10.19982/j.issn.1000-6621.20220194
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免疫细胞 | 治疗方式 | 作用机制 | 主要效果 |
---|---|---|---|
Vγ2Vδ2T细胞 | 体外扩增回输或者体内刺激γδT细胞增殖 | 识别MTB和宿主细胞的磷酸抗原 | 抗感染 |
固有自然杀伤T细胞 | 固有自然杀伤T细胞移植 | 释放大量IFN-γ进一步激活巨噬细胞,分泌粒细胞-巨噬细胞集落刺激因子 | 抑制MTB的增殖 |
黏膜相关固有T细胞 | 5-OP-RU疫苗刺激 | 分泌IFN-γ、TNF-α,启动CD4+T 细胞,减少靶器官MTB菌落数 | 早期感染控制 |
调节性T细胞 | 抑制调节性T细胞增殖和活性 | 干扰树突状细胞对T细胞的激活,抑制Th1和Th17介导的免疫反应 | 提高免疫应答水平 |
细胞因子诱导的杀伤细胞 | 体外扩增和活化淋巴细胞后回输 | 具有T淋巴细胞强大的免疫活性和NK细胞的非主要组织相容性复合体限制的优点 | 提高MDR-TB的疗效 |
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