Abstract:

To investigate the differences between pure protein derivative of BCG (BCG-PPD) and pure protein derivative of tuberculin (TB-PPD) in tuberculosis screening. Relevant literatures published from the establishment of the databases to February 2022 were searched from PubMed, Embase, Medline, Cochrane Library, CNKI and Wanfang. Open Meta Analyst software was used for meta-analysis of the included literatures. Cochrane Risk of Bias Assessment tool with Rev Man 5.3 software was used to evaluate the quality of the literature. Finally, 7 articles were included, with a total of 36131 participants, including 18314 participants in BCG-PPD group and 17817 participants in TB-PPD group. Dichotomous random effect model was used to analyzed. The combined OR (95%CI) value was 2.072 (1.683-2.550), I²=78.73%, P<0.001, indicating high heterogeneity, and the source of heterogeneity should be further analyzed. The results of subgroup analysis showed that the OR (95%CI) value of students and newborns was 2.393 (2.132-2.686), I²=50.15%, P=0.091, and I² value decreased significantly. The OR (95%CI) value of tuberculosis patients in the subgroup was 0.481 (0.236-0.978), I²=0, P=0.043, and the fixed-effect model was used. Differences in the positive detection rate of TB-PPD and BCG-PPD in different populations were found. The positive detection rate of BCG-PPD is higher than that of TB-PPD in students and neonates, and the positive detection rate of TB-PPD was higher than that of BCG-PPD in tuberculosis patients.

Key words: Tuberculosis, Recombinant proteins, Tuberculin, Meta analysis