高效液相色谱-质谱联用法测定血浆中异烟肼及其代谢物浓度的研究

葛菲, 朱慧, 程凯, 陆宇, 徐建

Study on the determination of isoniazid and its metabolites concentration in plasma by high-performance liquid chromatography-mass spectrometry

Ge Fei, Zhu Hui, Cheng Kai, Lu Yu, Xu Jian

表7 高效液相色谱-质谱联用法检测临床血浆样本中异烟肼、乙酰肼、肼的浓度

化合物 浓度范围 (ng/ml) 浓度 ($\bar{x}±s$,ng/ml) 相对标准差 (%) 异烟肼 359.41~5866.71 2402.33±1248.57 51.97 乙酰肼 667.11~2997.79 1902.51±596.82 31.37 肼 4.38~112.66 26.50±17.13 64.62