高效液相色谱-质谱联用法测定血浆中异烟肼及其代谢物浓度的研究
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葛菲, 朱慧, 程凯, 陆宇, 徐建
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Study on the determination of isoniazid and its metabolites concentration in plasma by high-performance liquid chromatography-mass spectrometry
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Ge Fei, Zhu Hui, Cheng Kai, Lu Yu, Xu Jian
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表3 高效液相色谱-质谱联用法测定化合物的准确度和精密度结果
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化合物及
浓度
(ng/ml) | 日内(6份) | 日间(6份) | 日内实测值
($\bar{x}±s$,ng/ml) | 相对误差
(%) | 相对标准
差(%) | 日间实测值
($\bar{x}±s$,ng/ml) | 相对误差
(%) | 相对标准
差(%) | | 异烟肼 | | | | | | | | 50 | 50.97±1.28 | 1.93 | 2.49 | 50.35±4.40 | 0.70 | 8.74 | | 150 | 143.03±2.46 | -4.65 | 1.91 | 144.84±8.11 | -3.44 | 5.60 | | 2500 | 2339.24±38.19 | -6.43 | 1.44 | 2351.34±184.65 | -5.95 | 7.85 | | 4500 | 4343.54±66.61 | -3.48 | 1.55 | 4276.56±273.83 | -4.97 | 6.40 | | 乙酰肼 | | | | | | | | 25 | 24.43±0.62 | -2.29 | 1.57 | 25.18±1.87 | 0.73 | 7.44 | | 75 | 73.45±3.47 | -2.07 | 4.74 | 74.04±4.31 | -1.28 | 5.83 | | 1250 | 1246.71±26.09 | -0.26 | 2.34 | 1203.44±81.71 | -3.72 | 6.79 | | 2250 | 2272.32±27.16 | 0.99 | 1.34 | 2173.46±153.35 | -3.40 | 7.06 | | 肼 | | | | | | | | 1 | 0.99±0.08 | -1.00 | 7.05 | 1.02±0.09 | 1.43 | 11.76 | | 3 | 3.08±0.12 | 2.53 | 3.90 | 3.03±0.24 | 0.96 | 7.94 | | 50 | 51.67±2.76 | 3.33 | 5.81 | 48.96±2.91 | -2.08 | 5.95 | | 90 | 93.48±1.94 | 3.86 | 2.32 | 88.87±5.23 | -1.25 | 5.89 |
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