13种抗生素对快生长分枝杆菌的体外抑菌效果评价
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于霞, 任汝颜, 文舒安, 梁倩, 董玲玲, 黄海荣
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Evaluation of in vitro antibacterial effects of 13 antibiotics against rapidly growing mycobacteria
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YU Xia, REN Ru-yan, WEN Shu-an, LIANG Qian, DONG Ling-ling, HUANG Hai-rong
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表3 脓肿分枝杆菌临床分离株的药物敏感性试验结果
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| 药品 | MIC 临界浓度(μg/ml)a | 脓肿分枝杆菌(70株) | | 敏感 | 临界浓度 | 耐药 | MIC范围
(μg/ml) | MIC50
(μg/ml) | MIC90
(μg/ml) | 敏感菌株[株
(敏感率,%)] | | 阿米卡星 | ≤16 | 32 | ≥64 | 1~32 | 16 | 16 | 63(90.0) | | 妥布霉素 | ≤2 | 4 | ≥8 | 2~>16 | 16 | >16 | 1(1.4) | | 阿莫西林-克拉维酸 | - | - | - | 64/32~>64/32 | 64/32 | >64/32 | - | | 头孢西丁 | ≤16 | 32~64 | ≥128 | 16~>128 | 128 | >128 | 1(1.4) | | 亚胺培南 | ≤4 | 8~16 | ≥32 | 8~>64 | >64 | >64 | 0(0.0) | | 环丙沙星 | ≤1 | 2 | ≥4 | 0.12~>4 | >4 | >4 | 3(4.3) | | 莫西沙星 | ≤1 | 2 | ≥4 | 2~>8 | >8 | >8 | 3(4.3) | | 克拉霉素 | ≤2 | 4 | ≥8 | 0.06~>16 | 1 | 16 | 43(61.4) | | 利奈唑胺 | ≤8 | 16 | ≥32 | 2~>32 | 32 | >32 | 2(2.9) | | 米诺环素 | ≤1 | 2~4 | ≥8 | 1~>8 | >8 | >8 | 2(2.9) | | 多西霉素 | ≤1 | 2~4 | ≥8 | 0.12~>16 | >16 | >16 | 2(2.9) | | 替加环素b | - | - | - | 0.06~>4 | 1 | 4 | 51(72.9) | | 甲氧苄啶-磺胺甲噁唑 | ≤2/38 | - | ≥4/76 | 0.25/4.75~8/152 | >8/152 | >8/152 | 3(4.3) |
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