Analysis of the epidemiological characteristics of rifampicin-resistant pulmonary tuberculosis in Ganzhou, Jiangxi from 2019 to 2020

doi:10.3969/j.issn.1000-6621.2021.12.010

Abstract

Abstract:

Objective Analysis of the epidemic characteristics of rifampicin-resistant pulmonary tuberculosis (“RR-TB” for short) in Ganzhou, Jiangxi from 2019 to 2020. Methods The data of medical record information and drug resistance of registered patients with tuberculosis in Ganzhou City from January 1, 2019 to December 31, 2020 were derived from the Tuberculosis Management Information System, a subsystem of China Disease Control and Prevention Information System. The status of cases tested for resistance and epidemiological characteristics of RR-TB cases were analyzed. Results Among the 10508 pulmonary tuberculosis patients who registered in Ganzhou from 2019 to 2020, there were 5897 bacteriologically confirmed cases. The proportion of bacteriologically confirmed tuberculosis cases tested for rifampicin resistance was 93.18% (5495/5897), and the prevalence of rifampicin resistance was 5.55% (305/5495). The proportion of RR-TB cases from new bacteriologically confirmed retreatment bacteriologically confirmed tuberculosis cases and from retreatment bacteriologically confirmed tuberculosis cases were 49.51% (151/305) and 50.49% (154/305), respectively. The prevalence of rifampicin resistance among who aged 20-59 years (6.25% (199/3186)) was significantly higher than that among who aged 0-19 years (3.74% (8/214)) and who aged greater than 60 years (4.68% (98/2095));the prevalence of rifampicin resistance among Nankang District (9.06% (30/331)) of urban and neighboring suburbs was significantly higher than that among Shicheng County (1.35% (3/222)) of outside suburban district. The differences were statistically significant (the Chi Squares were 7.324,766.858, and the P values were 0.026,0.001). Conclusion Rifampicin resistant tuberculosis has became an important challenge in the prevention and control of tuberculosis in economic undeveloped areas. Standard treatment and infection control should be further strengthened to reduce the occurrence of drug resistance,young and middle-aged population and cases in urban and neighboring suburbs should be the key populations.

Key words: Tuberculosis,pulmonary, Tuberculosis,multidrug-resistant, Rifampicin, Epidemiologic study characteristics as topic

WANG Meng, WAN Yi-you, XIE Tian, LI Jian-hua, RUAN Yun-zhou, LIU Yue-yuan, HU Jia, FENG De-an, GUO Hui-ying, LI Ren-zhong. Analysis of the epidemiological characteristics of rifampicin-resistant pulmonary tuberculosis in Ganzhou, Jiangxi from 2019 to 2020[J]. Chinese Journal of Antituberculosis, 2021, 43(12): 1287-1291. doi: 10.3969/j.issn.1000-6621.2021.12.010

Figures/Tables 4

References 12

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年份	肺结核 (例)	病原学阳性		固体培养耐药筛查		Xpert耐药筛查		筛查合计		利福平耐药
年份	肺结核 (例)	例数	阳性率 (%)	例数	构成比 (%)	例数	构成比 (%)	例数	筛查率 (%)	例数	耐药率 (%)
2019	5790	3013	52.04	110	4.10	2571	95.90	2681	88.98	160	5.97
2020	4718	2884	61.13	6	0.21	2808	99.79	2814	97.57	145	5.15
合计	10508	5897	56.12	116	2.11	5379	97.89	5495	93.18	305	5.55

来源分类	2019年			2020年			合计
来源分类	耐药筛查 (例)	利福平耐药(例)	耐药率 (%)	耐药筛查 (例)	利福平耐药(例)	耐药率 (%)	耐药筛查 (例)	利福平耐药(例)	耐药率 (%)
新发病原学阳性	2126	70	3.29	2318	81	3.49	4444	151	3.40
复治病原学阳性	519	84	16.18	532	70	13.16	1051	154	14.65
合计	2645	154	5.82	2850	151	5.30	5495	305	5.55

特征	2019年			2020年			合计
特征	耐药筛查 (例)	利福平耐药(例)	耐药率 (%)	耐药筛查 (例)	利福平耐药(例)	耐药率 (%)	耐药筛查 (例)	利福平耐药(例)	耐药率 (%)
性别
男性	2083	125	6.00	2240	122	5.45	4323	247	5.71
女性	562	29	5.16	610	29	4.75	1172	58	4.95
年龄组(岁)
0~19	115	5	4.35	99	3	3.03	214	8	3.74
20~59	1542	94	6.10	1644	105	6.39	3186	199	6.25
≥60	988	55	5.57	1107	43	3.88	2095	98	4.68
合计	2645	154	5.82	2850	151	5.30	5495	305	5.55

县(区)	2019年			2020年			合计
县(区)	耐药筛查 (例)	利福平耐药(例)	耐药率 (%)	耐药筛查 (例)	利福平耐药(例)	耐药率 (%)	耐药筛查 (例)	利福平耐药(例)	耐药率 (%)
章贡区	276	28	10.14	269	17	6.32	545	45	8.26
南康区	191	15	7.85	140	15	10.71	331	30	9.06
赣县区	108	10	9.26	218	8	3.67	326	18	5.52
信丰县	140	11	7.86	313	14	4.47	453	25	5.52
大余县	82	5	6.10	117	7	5.98	199	12	6.03
上犹县	160	4	2.50	118	5	4.24	278	9	3.24
崇义县	43	2	4.65	47	4	8.51	90	6	6.67
安远县	118	7	5.93	88	4	4.55	206	11	5.34
龙南县	179	10	5.59	194	9	4.64	373	19	5.09
定南县	85	0	0.00	54	5	9.26	139	5	3.60
全南县	50	3	6.00	73	3	4.11	123	6	4.88
宁都县	139	5	3.60	138	6	4.35	277	11	3.97
于都县	305	24	7.87	336	17	5.06	641	41	6.40
兴国县	210	12	5.71	237	17	7.17	447	29	6.49
会昌县	148	3	2.03	132	5	3.79	280	8	2.86
寻乌县	87	2	2.30	113	7	6.19	200	9	4.50
石城县	135	2	1.48	87	1	1.15	222	3	1.35
瑞金市	189	11	5.82	176	7	3.98	365	18	4.93
赣州市	2645	154	5.82	2850	151	5.30	5495	305	5.55

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