Abstract: Objective  To explore the psychological state and need of psychological support of multi-drug resistant tuberculosis (MDR-TB) patients. Methods  Face-to-face questionnaire interview was conducted to 51 MDR-TB patients who finished 3 questionnaires of all 100 MDR-TB patients enrolled in Kaifeng TB Control Institute in Henan and the Second Hospital of Yongchuan in Chongqing during Mar. 1 2011 to Feb. 29 2012. Out of the 51 subjects, there are 86.3%（44/51） male, 66.7%（34/51） farmers, and 39.2%（20/51） with primary education and below, whose average age are（46.9±12.8）years. Results  The psychological state of MDR-TB patients were statistically improved during their treatment. Patients’ psychological pressure decreased along with the treatment. The percentage of patients without pressure increased from 21.6%（11/51） at the entry of hospitalization to 35.3%（18/51） as discharging from hospital and finally to 70.6%（36/51） after 6 months of treatment（χ²=39.9，P<0.01）.   Conclusion  Effective medical treatment can improve MDR-TB patients’psychological state.

Key words: Tuberculosis,pulmonary/psychology, Psychotherapy, Health promotion, Drug resistance, multiple, bacterial