Abstract: Objective  To understand the drug resistance of retreatment tuberculosis patients in Beijing, and to provide evidence for Beijing TB control.  Methods  One hundred and ninty-five retreatment tuberculosis patients registered in TB control organizations from 2009 to 2010 that had performed both the 1st-line and 2nd-line drug susceptibility tests were collected and analyzed. Chi-square test was used for comparing difference of drug resistant rate,  α=0.05.     Results  The resistance rate of 1st-line anti-TB drugs was 56.4%（110/195）, for 2nd-line anti-TB drug resistance rate was 63.6%（124/195）, multi-drug resistant(MDR) rate was 28.2%（55/195）,extensively-drug resistant(XDR) rate was 3.1%（6/195）. Drug resistance rate in the top 5 of the 9 drugs tested were Pto 57.9%(113/195), INH 42.6%(83/195), EMB 36.4%(71/195), S 34.9%(68/195) and RFP 33.8%(66/195).There were no significant difference of drug resistance in different gender［male 788%(119/151)，female 79.5% (35/44)，χ²=0.011, P>0.05］, age group［“15～years old” 82.9%(34/41), “30～years old” 83.8%(57/68), “45～years old” 79.2%(38/48), “60～years old”  65.8%(25/38)，χ²=5.328, P>0.05］, region［local census register,79.2%(103/130),Nonlocal census register 78.5% (51/65)，χ²=0.015, P>0.05］and patient classification ［relapse 77.7%(122/157), initial treatment failure 84.6%(11/13),other retreatment 840%(21/25), χ²=0.824, P>0.05］.  Conclusion  The drug resistance of retreatment tuberculosis is serious in Beijing. We should strengthen the research on existing treatment methods in TB control in order to meet the evolving needs of capital tuberculosis control under the new situation.

Key words: Tuberculosis, pulmonary, Mycobacterium tuberculosis, Drug resistance, bacterial, Beijing city