Abstract: Tuberculosis is a respiratory infectious disease caused by Mycobacterium tuberculosis, and the situation of tuberculosis (TB) in the world is still very severe. While the effect of currently available vaccine Bacillus Calmette-Guérin (BCG) against TB, is not ideal. A new tuberculosis vaccine has become one of the hotspots in the research of tuberculosis at home and abroad. This article will introduce the immunogenicity and therapeutic effects of Mtb Ag85A DNA vaccine in the mouse tuberculosis model from our research team since 1998. The results showed that Mtb Ag85A DNA vaccine could induce humoral immune and Th1 cell immune responses in mice, reduce M. tuberculosis, especially multi-drug-resistant M. tuberculosis in the organs of mice. The vaccine combined with conventional chemotherapy can improve the immunity, and effectively kill or inhibit M. tuberculosis, so as to improve the effect of chemotherapy.

Key words: Vaccines, DNA, Ag85A, Antigens, Bacterial, Tuberculosis/therapy